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Evidence of False Positivity forVibrioSpecies Tested by Gastrointestinal Multiplex PCR Panels, Minnesota, 2016–2018 by Decuir, Marijke (author);Fowler, Randal C (author);Cebelinski, Elizabeth (author);Smith, Kirk (author);Boxrud, David (author);Medus, Carlota (author) is a Medicine article available to read on EtoBox.

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## Abstract ## Background Syndromic gastrointestinal multiplex polymerase chain reaction (PCR) panels (GMPPs) are used by an increasing number of clinical laboratories to identify enteric pathogens. Vibrio species are included on GMPPs, but because of the low prevalence of vibriosis, performance characteristics for these panels have been difficult to measure. ## Methods All Vibrio spp. cases identified by GMPPs in Minnesota during 2016–2018 (n = 100) were assessed to identify differences between culture-confirmed cases and those that were PCR-positive only. ## Results Overall, 47% of cases had Vibrio species recovered by culture. Two GMPPs were used in Minnesota, Verigene EPT and FilmArray GIP, and the recovery rate of Vibrio spp. was significantly different between these platforms (Verigene EPT 63%, compared with FilmArray GIP 28%). No distinct seasonality was identified among GMPP-positive, culture-negative cases, whereas culture-confirmed case incidence peaked during July and August. Among cases with no other pathogen detected by the GMPP, confirmed cases reported a lower rate of bloody diarrhea (odds ratio [OR], 0.7; P = .004) and were less likely to have a symptom duration >14

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Author

Decuir, Marijke (author);Fowler, Randal C (author);Cebelinski, Elizabeth (author);Smith, Kirk (author);Boxrud, David (author);Medus, Carlota (author)

Publisher

Oxford University Press (OUP)

Published

2021

Language

EN

Field

Medicine (Health Sciences)