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Yam-derived Exosome-like Nanovesicles Stimulate Osteoblast Formation and Prevent Osteoporosis in Mice by Jin-Hyeon Hwang; Yu-Seong Park; Hyuk-Soon Kim; Dong-ha Kim; Sang-Hoon Lee; Chan-Hyeong Lee; Seung-Hoon Lee; Jung-Eun Kim; Sangkyu Lee; Ho Min Kim; Hyun-Woo Kim; Jihoon Kim; Wonhyo Seo; Hyo-Jung Kwon; Byoung-Joon Song; Do-Kyun Kim; Moon-Chang Baek; Young-Eun Cho is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Yam-derived Exosome-like Nanovesicles Stimulate Osteoblast Formation and Prevent Osteoporosis in Mice about?
Plants-releasing exosome-like nanovesicles (PENs) contain miRNA, bioactive lipids, mRNAs, and proteins to exert antioxidant, anti-inflammatory, and regenerative activity. Substances extracted from yams have been reported to promote osteoblast growth in bone regeneration, which prevent weak and brittle bones in osteoporosis. Herein, we describe the beneficial effects of yam-derived exosome-like nanovesicles (YNVs) on promoting differentiation and mineralization of osteoblasts for bone regeneration in ovariectomized (OVX)-induced osteoporotic mice. YNVs were successfully isolated and characterized. YNVs stimulate the proliferation, differentiation, and mineralization of osteoblasts with increased bone differentiation markers (OPN, ALP, and COL -I). Interestingly, YNVs do not contain saponins including diosgenin and dioscin known to mainly exert osteogenic activity of yams. Instead, the osteogenic activity of YNVs was revealed to be resulted from activation of the BMP-2/p-p38dependent Runx2 pathway. As a result, YNVs promote longitudinal bone growth and mineral density of the tibia in the OVX-induced osteoporotic mice in vivo, and these results positively correlate the significant inc
Who reads Yam-derived Exosome-like Nanovesicles Stimulate Osteoblast Formation and Prevent Osteoporosis in Mice?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Jin-Hyeon Hwang; Yu-Seong Park; Hyuk-Soon Kim; Dong-ha Kim; Sang-Hoon Lee; Chan-Hyeong Lee; Seung-Hoon Lee; Jung-Eun Kim; Sangkyu Lee; Ho Min Kim; Hyun-Woo Kim; Jihoon Kim; Wonhyo Seo; Hyo-Jung Kwon; Byoung-Joon Song; Do-Kyun Kim; Moon-Chang Baek; Young-Eun Cho
- Publisher
- Elsevier BV
- Published
- 2023
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)