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Can I read Post-acute Blood Biomarkers and Disease Progression in Traumatic Brain Injury on EtoBox?
Post-acute Blood Biomarkers and Disease Progression in Traumatic Brain Injury by Virginia F J Newcombe; Nicholas J Ashton; Jussi P Posti; Ben Glocker; Anne Manktelow; Doris A Chatfield; Stefan Winzeck; Edward Needham; Marta M Correia; Guy B Williams; Joel Simrén; Riikka S K Takala; Ari J Katila; Henna Riikka Maanpää; Jussi Tallus; Janek Frantzén; Kaj Blennow; Olli Tenovuo; Henrik Zetterberg; David K Menon is a Neuroscience article available to read on EtoBox.
What is Post-acute Blood Biomarkers and Disease Progression in Traumatic Brain Injury about?
## Abstract There is substantial interest in the potential for traumatic brain injury to result in progressive neurological deterioration. While blood biomarkers such as glial fibrillary acid protein (GFAP) and neurofilament light have been widely explored in characterizing acute traumatic brain injury (TBI), their use in the chronic phase is limited. Given increasing evidence that these proteins may be markers of ongoing neurodegeneration in a range of diseases, we examined their relationship to imaging changes and functional outcome in the months to years following TBI. Two-hundred and three patients were recruited in two separate cohorts; 6 months post-injury (__n__ = 165); and >5 years post-injury (__n__ = 38; 12 of whom also provided data ∼8 months post-TBI). Subjects underwent blood biomarker sampling (__n__ = 199) and MRI (__n__ = 172; including diffusion tensor imaging). Data from patient cohorts were compared to 59 healthy volunteers and 21 non-brain injury trauma controls. Mean diffusivity and fractional anisotropy were calculated in cortical grey matter, deep grey matter and whole brain white matter. Accelerated brain ageing was calculated at a whole brain level as the p
Who reads Post-acute Blood Biomarkers and Disease Progression in Traumatic Brain Injury?
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- Virginia F J Newcombe; Nicholas J Ashton; Jussi P Posti; Ben Glocker; Anne Manktelow; Doris A Chatfield; Stefan Winzeck; Edward Needham; Marta M Correia; Guy B Williams; Joel Simrén; Riikka S K Takala; Ari J Katila; Henna Riikka Maanpää; Jussi Tallus; Janek Frantzén; Kaj Blennow; Olli Tenovuo; Henrik Zetterberg; David K Menon
- Publisher
- Oxford University Press (OUP)
- Published
- 2022
- Language
- EN
- Field
- Neuroscience (Life Sciences)