Opening book details…
Can I read Novel endocrine therapies: What is next in estrogen receptor positive, HER2 negative breast cancer? on EtoBox?
Novel endocrine therapies: What is next in estrogen receptor positive, HER2 negative breast cancer? by Chiara Corti; Carmine De Angelis; Giampaolo Bianchini; Luca Malorni; Mario Giuliano; Erika Hamilton; Rinath Jeselsohn; Komal Jhaveri; Giuseppe Curigliano; Carmen Criscitiello is a Medicine article available to read on EtoBox.
What is Novel endocrine therapies: What is next in estrogen receptor positive, HER2 negative breast cancer? about?
Endocrine therapy (ET) is the cornerstone of management in hormone receptor (HR)+ breast cancer (BC). Indeed, targeting the estrogen receptor (ER) signaling at different levels is a successful strategy, since BC largely relies on the ER signaling as a driver of tumorigenesis and progression. In metastatic BC, progression of disease typically occurs due to either ligand-independent ER signaling, which favors tumor proliferation and survival in the absence of hormonal stimuli, or an ER-independent signaling, which exploits alternative transcription pathways. For instance, estrogen receptor 1 (ESR1) mutations induce constitutive ER activity, in turn upregulating ER-dependent gene transcription and causing resistance to estrogen depleting therapies. The largest unmet need lies after progression on ET + cyclin-dependent kinases 4 and 6 (CDK4/6) inhibitors, where fulvestrant alone provides an average 2–3-month PFS. In this context, novel oral selective estrogen receptor degraders (SERDs) and other next-generation ETs are being investigated, both as single agents and in combination with targeted therapies. Elacestrant, the next generation ET in most advanced clinical development and the f
Who reads Novel endocrine therapies: What is next in estrogen receptor positive, HER2 negative breast cancer??
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Chiara Corti; Carmine De Angelis; Giampaolo Bianchini; Luca Malorni; Mario Giuliano; Erika Hamilton; Rinath Jeselsohn; Komal Jhaveri; Giuseppe Curigliano; Carmen Criscitiello
- Publisher
- Elsevier BV
- Published
- 2023
- Language
- EN
- Field
- Medicine (Health Sciences)