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The Impact of Tissue Detection on Diagnostic Artificial Intelligence Algorithms in Digital Pathology by Boman, Sol Erika; Mulliqi, Nita; Blilie, Anders; Ji, Xiaoyi; Szolnoky, Kelvin; Gudlaugsson, Einar; Janssen, Emiel A. M.; Kjosavik, Svein R.; Asenjo, José; Gambacorta, Marcello; Libretti, Paolo; Braun, Marcin; Kordek, Radzislaw; Łowicki, Roman; Hotakainen, Kristina; Väre, Päivi; Pedersen, Bodil Ginnerup; Sørensen, Karina Dalsgaard; Ulhøi, Benedicte Parm; Egevad, Lars; Kartasalo, Kimmo is a scholarly article available to read on EtoBox.

What is The Impact of Tissue Detection on Diagnostic Artificial Intelligence Algorithms in Digital Pathology about?

Tissue detection is a crucial first step in most digital pathology applications. Details of the segmentation algorithm are rarely reported, and there is a lack of studies investigating the downstream effects of a poor segmentation algorithm. Disregarding tissue detection quality could create a bottleneck for downstream performance and jeopardize patient safety if diagnostically relevant parts of the specimen are excluded from analysis in clinical applications. This study aims to determine whether performance of downstream tasks is sensitive to the tissue detection method, and to compare performance of classical and AI-based tissue detection. To this end, we trained an AI model for Gleason grading of prostate cancer in whole slide images (WSIs) using two different tissue detection algorithms: thresholding (classical) and UNet++ (AI). A total of 33,823 WSIs scanned on five digital pathology scanners were used to train the tissue detection AI model. The downstream Gleason grading algorithm was trained and tested using 70,524 WSIs from 13 clinical sites scanned on 13 different scanners. There was a decrease from 116 (0.43%) to 22 (0.08%) fully undetected tissue samples when switching f

Author

Boman, Sol Erika; Mulliqi, Nita; Blilie, Anders; Ji, Xiaoyi; Szolnoky, Kelvin; Gudlaugsson, Einar; Janssen, Emiel A. M.; Kjosavik, Svein R.; Asenjo, José; Gambacorta, Marcello; Libretti, Paolo; Braun, Marcin; Kordek, Radzislaw; Łowicki, Roman; Hotakainen, Kristina; Väre, Päivi; Pedersen, Bodil Ginnerup; Sørensen, Karina Dalsgaard; Ulhøi, Benedicte Parm; Egevad, Lars; Kartasalo, Kimmo

Published

2025

Language

EN