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Can I read Esculentin 1–21: a Linear Antimicrobial Peptide from Frog Skin with Inhibitory Effect on Bovine Mastitis-causing Bacteria on EtoBox?
Esculentin 1–21: a Linear Antimicrobial Peptide from Frog Skin with Inhibitory Effect on Bovine Mastitis-causing Bacteria by Alfonso Enrique Islas-Rodrìguez; Ludovica Marcellini; Barbara Orioni; Donatella Barra; Lorenzo Stella; Maria Luisa Mangoni is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Esculentin 1–21: a Linear Antimicrobial Peptide from Frog Skin with Inhibitory Effect on Bovine Mastitis-causing Bacteria about?
## Abstract Mastitis, or inflammation of the mammary gland, is the most common and expensive illness of dairy cows throughout the world. Although stress and physical injuries may give rise to inflammation of the udders, infections by bacteria or other microorganisms remain the major cause, and infusion of antibiotics is the main treatment approach. However, the increased emergence of multidrug‐resistant pathogens and the production of milk contaminated with antibiotics has become a serious threat in the livestock. Hence, there is an urgent need for the discovery of new therapeutic agents with a new mode of action. Gene‐encoded AMPs, which represent the first line of defence in all living organisms, are considered as promising candidates for the development of new anti‐infective agents. This paper reports on the antibacterial activities __in vitro__ and in an animal model, of the frog skin AMP esculentin 1–21 [Esc(1–21)], along with a plausible mode of action. Our data revealed that this peptide (i) is highly potent against the most common mastitis‐causing microbes (e.g. __Streptococcus agalactiae)__; and (ii) is active __in vivo__, causing a visible regression of the clinical stage
Who reads Esculentin 1–21: a Linear Antimicrobial Peptide from Frog Skin with Inhibitory Effect on Bovine Mastitis-causing Bacteria?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Alfonso Enrique Islas-Rodrìguez; Ludovica Marcellini; Barbara Orioni; Donatella Barra; Lorenzo Stella; Maria Luisa Mangoni
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1075-2617)
- Published
- 2009
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)