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A Cancer Cell Membrane Coated Nanoparticles-based Gene Delivery System for Enhancing Cancer Therapy by Zhou Fang; Min Zhang; Rui Kang; Mingxiao Cui; Mengdi Song; Kehai Liu is a Pharmacology, Toxicology and Pharmaceutics article available to read on EtoBox.

What is A Cancer Cell Membrane Coated Nanoparticles-based Gene Delivery System for Enhancing Cancer Therapy about?

Gene therapy is a superior therapeutic means in cancer therapy. However, the instability of nucleic acid and the lack of suitable delivery carrier greatly restricts its further development and application. Herein, we coupled low molecular weight polyethyleneimine (LMW PEI) through disulfide bonds, then modified it with manganese dioxide (MnO2) nanosheets and nuclear localization signal peptide (NLS), as a p53 gene carrier, and finally coated it with B16F10 cell membrane to construct a novel gene-carrier system CM@MnO2-PEI-NLS-ss/p53 (M@MPNs/p53). Tumor cell membrane coating endows nanoparticles with homotypic targeting and immune escape capabilities, disulfide-crosslinked LMW-PEI has high transfection efficiency and low toxicity, and NLS peptides enhance nuclear delivery and improve p53 gene delivery efficiency; meanwhile, MnO2 nanosheets oxidize high intracellular concentration of glutathione (GSH), sensitizing p53 gene-mediated antitumor therapy. The results showed that the novel biofilm-camouflaged M@MPNs/p53 nanoparticles had a highly specific targeting effect on homologous cancer cells and could effectively inhibit tumor growth in vitro and in vivo. Besides, MnO2 loading impro

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Author

Zhou Fang; Min Zhang; Rui Kang; Mingxiao Cui; Mengdi Song; Kehai Liu

Publisher

Elsevier BV

Published

2022

Language

EN

Field

Pharmacology, Toxicology and Pharmaceutics (Life Sciences)