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A novel, bedside, etiology specific prognostic model (Peds-HAV) in hepatitis A induced pediatric acute liver failure by Bikrant Bihari Lal; Vikrant Sood; Pandey Snehavardhan; Rajeev Khanna; Samba Siva Rao Pasupuleti; Manish Siloliya; Guresh Kumar; Seema Alam is a Medicine article available to read on EtoBox.

What is A novel, bedside, etiology specific prognostic model (Peds-HAV) in hepatitis A induced pediatric acute liver failure about?

## Background: Hepatitis a virus (hav) is the commonest cause of pediatric acute liver failure (palf) in developing countries. our objective was to develop and validate a hav-etiology specific prognostic model in palf. ## Methods: All children with hav induced palf (igm hav reactive) were included. outcome was defined at day 28. only those with death or native liver survival were included. the model (peds-hav) was derived using the independent predictors of outcome and validated in a prospective independent cohort. ## Results: Hepatitis a accounted for 131 (45.9%) of total 285 palf. after excluding 11 children who underwent liver transplant, 120 children (74 survivors and 46 death) were included. the first 75 patients formed the derivation cohort and the next 45 patients formed the prospective validation cohort. in the derivation cohort, inr: or 2.208, (95% ci 1.321-3.690), p = 0.003, grade of hepatic encephalopathy (he): or 3.078, (95% ci 1.017-9.312), p = 0.047 and jaundice-to-he interval: or 1.171, (95% ci 1.044-1.314), p = 0.007 were independent predictors of death. the final model comprised three criteria: (1) presence of grade 3-4 he, (2) inr greater than 3.1, and (3) jaundic

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Author

Bikrant Bihari Lal; Vikrant Sood; Pandey Snehavardhan; Rajeev Khanna; Samba Siva Rao Pasupuleti; Manish Siloliya; Guresh Kumar; Seema Alam

Publisher

Springer-Verlag; Springer India; Springer Science and Business Media LLC; Society for Mining, Metallurgy and Exploration Inc. (ISSN 1936-0533)

Published

2020

Language

EN

Field

Medicine (Health Sciences)