Can I read Polyglutamine Disorders Volume 1049 on EtoBox?

Polyglutamine Disorders Volume 1049 by Nóbrega, Clévio; Pereira de Almeida, Luís is a scholarly article available to read on EtoBox.

What is Polyglutamine Disorders Volume 1049 about?

This book provides a cutting-edge review of polyglutamine disorders. It primarily focuses on two main aspects: (1) the mechanisms underlying the pathologies’ development and progression, and (2) the therapeutic strategies that are currently being explored to stop or delay disease progression.  Polyglutamine (polyQ) disorders are a group of inherited neurodegenerative diseases with a fatal outcome that are caused by an abnormal expansion of a coding trinucleotide repeat (CAG), which is then translated in an abnormal protein with an elongated glutamine tract (Q). To date, nine polyQ disorders have been identified and described: dentatorubral-pallidoluysian atrophy (DRPLA); Huntington’s disease (HD); spinal–bulbar muscular atrophy (SBMA); and six spinocerebellar ataxias (SCA 1, 2, 3, 6, 7, and 17). The genetic basis of polyQ disorders is well established and described, and despite important advances that have opened up the possibility of generating genetic models of the disease, the mechanisms that cause neuronal degeneration are still largely unknown and there is currently no treatment available for these disorders. Further, it is believed that the different polyQ may share some mech

Author

Nóbrega, Clévio; Pereira de Almeida, Luís

Publisher

Springer International Publishing : Imprint : Springer

Published

2018

Language

EN

ISBN

9783319717784