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Prospective Randomized Double-blind Trial of Neurolytic Coeliac Plexus Block in Patients with Pancreatic Cancer by E. Polati; G. Finco; Dr L. Gottin; C. Bassi; P. Pederzoli; I. Ischia is a Medicine article available to read on EtoBox.

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## Abstract ## Background In a randomized double-blind study the efficacy of neurolytic coeliac plexus block (NCPB) was compared with pharmacological therapy in the treatment of pain from pancreatic cancer. ## Methods Twenty-four patients were divided into two groups: 12 patients underwent NCPB (group 1) and 12 were treated with pharmacological therapy (group 2). Immediate and long-term efficacy, mean analgesic consumption, mortality and morbidity were evaluated at follow-up. Statistical analysis was performed with the unpaired t test, Mann–Whitney U test and Fisher's exact test. ## Results Immediately after the block, patients in group 1 reported significant pain relief compared with those in group 2 (P < 0·05), but long-term results did not differ between the groups. Mean analgesic consumption was lower in group 1. There were no deaths. Complications related to NCPB were transient diarrhoea and hypotension (P not significant between groups). Drug-related adverse effects were constipation (five of 12 patients in group 1 versus12 of 12 in group 2), nausea and/or vomiting (four of 12 patients in group 1 versus 12 of 12 in group 2) (P < 0·05), one gastric ulcer and one gluteal absces

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Author

E. Polati; G. Finco; Dr L. Gottin; C. Bassi; P. Pederzoli; I. Ischia

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Oxford University Press (OUP) (ISSN 0007-1323)

Published

1998

Language

EN

Field

Medicine (Health Sciences)