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Self-reported health behaviors and longitudinal cognitive performance in late middle age: Results from the Wisconsin Registry for Alzheimer’s Prevention by Mueller, Kimberly D.; Norton, Derek; Koscik, Rebecca L.; Morris, Martha C.; Jonaitis, Erin M.; Clark, Lindsay R.; Fields, Taylor; Allison, Samantha; Berman, Sara; Kraning, Sarah; Zuelsdorff, Megan; Okonkwo, Ozioma; Chin, Nathaniel; Carlsson, Cynthia M.; Bendlin, Barbara B.; Hermann, Bruce P.; Johnson, Sterling C.; Ginsberg, Stephen D. is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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## Background Studies have suggested associations between self-reported engagement in health behaviors and reduced risk of cognitive decline. Most studies explore these relationships using one health behavior, often cross-sectionally or with dementia as the outcome. In this study, we explored whether several individual self-reported health behaviors were associated with cognitive decline when considered simultaneously, using data from the Wisconsin Registry for Alzheimer’s Prevention (WRAP), an Alzheimer’s disease risk-enriched cohort who were non-demented and in late midlife at baseline. ## Method We analyzed longitudinal cognitive data from 828 participants in WRAP, with a mean age at baseline cognitive assessment of 57 (range = 36–78, sd = 6.8) and an average of 6.3 years (standard deviation = 1.9, range = 2–10) of follow-up. The primary outcome was a multi-domain cognitive composite, and secondary outcomes were immediate/delayed memory and executive function composites. Predictors of interest were self-reported measures of physical activity, cognitive activity, adherence to a Mediterranean-style diet (MIND), and interactions with each other and age. We conducted linear mixed ef

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Author

Mueller, Kimberly D.; Norton, Derek; Koscik, Rebecca L.; Morris, Martha C.; Jonaitis, Erin M.; Clark, Lindsay R.; Fields, Taylor; Allison, Samantha; Berman, Sara; Kraning, Sarah; Zuelsdorff, Megan; Okonkwo, Ozioma; Chin, Nathaniel; Carlsson, Cynthia M.; Bendlin, Barbara B.; Hermann, Bruce P.; Johnson, Sterling C.; Ginsberg, Stephen D.

Publisher

Public Library of Science; San Francisco CA: Public Library of Science; Publons; ScienceOpen; Public Library of Science (PLoS) (ISSN 1932-6203)

Published

2020

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)