Can I read Activatable Type I Photosensitizer with Quenched Photosensitization Pre and Post Photodynamic Therapy on EtoBox?

Activatable Type I Photosensitizer with Quenched Photosensitization Pre and Post Photodynamic Therapy by Jianwu Tian; Bowen Li; Fu Zhang; Zhuo Yao; Wentao Song; Yufu Tang; Yuan Ping; Bin Liu is a Chemistry article available to read on EtoBox.

What is Activatable Type I Photosensitizer with Quenched Photosensitization Pre and Post Photodynamic Therapy about?

## Abstract The phototoxicity of photosensitizers (PSs) pre and post photodynamic therapy (PDT), and the hypoxic tumor microenvironment are two major problems limiting the application of PDT. While activatable PSs can successfully address the PS phototoxicity pre PDT, and type I PS can generate reactive oxygen species (ROS) effectively in hypoxic environment, very limited approaches are available for addressing the phototoxicity post PDT. There is virtually no solution available to address all these issues using a single design. Herein, we propose a proof‐of‐concept on‐demand switchable photosensitizer with quenched photosensitization pre and post PDT, which could be activated only in tumor hypoxic environment. Particularly, a hypoxia‐normoxia cycling responsive type I PS **TPFN‐AzoCF~3~** was designed to demonstrate the concept, which was further formulated into **TPFN‐AzoCF~3~** nanoparticles (NPs) using DSPE‐PEG‐2000 as the encapsulation matrix. The NPs could be activated only in hypoxic tumors to generate type I ROS during PDT treatment, but remain non‐toxic in normal tissues, pre or after PDT, thus minimizing side effects and improving the therapeutic effect. With promising re

Who reads Activatable Type I Photosensitizer with Quenched Photosensitization Pre and Post Photodynamic Therapy?

Author

Jianwu Tian; Bowen Li; Fu Zhang; Zhuo Yao; Wentao Song; Yufu Tang; Yuan Ping; Bin Liu

Publisher

Wiley

Published

2023

Field

Chemistry (Physical Sciences)