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Oridonin Alleviates IRI-Induced Kidney Injury by Inhibiting Inflammatory Response of Macrophages via AKT-Related Pathways by Ying Yan; Rui-zhi Tan; Peng Liu; Jian-chun Li; Xia Zhong; Yuan Liao; Xiao Lin; Cong Wei; Li Wang is a Medicine article available to read on EtoBox.
What is Oridonin Alleviates IRI-Induced Kidney Injury by Inhibiting Inflammatory Response of Macrophages via AKT-Related Pathways about?
## Background Acute kidney injury (AKI) is one of the most common complications in clinic, but there is still no effective treatment. Oridonin, extracted from __Rabdosia rubescens__, has been identified to promote inhibitory effects on tumor, inflammatory and fibrosis by previous study. This study aimed to assess the kidney-protective role of Oridonin in AKI and the underlying mechanism by which Oridonin improves AKI __in vivo__ and inhibits inflammation in LPS-induced bone marrow-derived macrophages (BMDM) __in vitro__. ## Material/Methods SPF C57BL/6J male mice (8–10 weeks old, body weight 20–25 g) were divided into 3 groups – sham group, AKI group, and Oridonin-treated AKI group – with 6 mice in each group. In the __in vitro__ study, LPS-induced inflammatory BMDM cells were treated with Oridonin and agonist of AKT. The expression and secretion levels of inflammation-related indicators and AKT-related signaling molecules were detected by real-time PCR, ELISA, Western blot, and immunofluorescence. Also, various methods are used to assess renal function and pathological changes. ## Results The results showed that Oridonin treatment significantly improved the serum creatinine and BU
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- Author
- Ying Yan; Rui-zhi Tan; Peng Liu; Jian-chun Li; Xia Zhong; Yuan Liao; Xiao Lin; Cong Wei; Li Wang
- Publisher
- International Scientific Information, Inc.
- Published
- 2020
- Language
- EN
- Field
- Medicine (Health Sciences)