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Prevention of Bleeding in Orthognathic Surgery—A Systematic Review and Meta-Analysis of Randomized Controlled Trials by Jesper J. Olsen; Jane Skov; Janne Ingerslev; Jens J. Thorn; Else M. Pinholt is a Medicine article available to read on EtoBox.

What is Prevention of Bleeding in Orthognathic Surgery—A Systematic Review and Meta-Analysis of Randomized Controlled Trials about?

The objective of the present study was to evaluate the efficacy of hemostatic adjuncts on intraoperative blood loss (IOB) in orthognathic surgery (OS) detected by randomized controlled trials (RCTs) of the highest quality. Materials and Methods: A search of the Medline, Cochrane, Embase, and Web of Science databases was performed in January 2015, and the risk of bias was assessed using the Jadad and Delphi scales. The predictor variable was the hemostatic measures, and the main outcome variable was the total IOB volume. The secondary outcome variables were the hemoglobin and hematocrit and operating time. This review is registered at PROSPERO (CRD42014014840). Results: Eleven trials were included for review. The individual trials demonstrated the effects on IOB from hypotensive anesthetic regimens, the use of aprotinin, and the herbal medicine Yunnan Baiyao. Six studies of tranexamic acid (TXA), with 288 patients, were suitable for a meta-analysis of continuous data. TXA reduced IOB by an average of 171 mL (95% confidence interval [CI] À230 to À112; P < .00001). Its topical use yielded similarly significant results (mean difference À197, 95% CI À319 to À76; P < .001). A subgroup an

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Author

Jesper J. Olsen; Jane Skov; Janne Ingerslev; Jens J. Thorn; Else M. Pinholt

Published

2016

Language

EN

Field

Medicine (Health Sciences)