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Can I read Novel Biomarkers Associated with Thoracic Aortic Disease on EtoBox?
Novel Biomarkers Associated with Thoracic Aortic Disease by Carlijn G.E. Thijssen; Silvy Dekker; Lidia R. Bons; Laurie W. Geenen; Arjen L. Gökalp; Johanna J.M. Takkenberg; Mostafa M. Mokhles; Jos A. Bekkers; Eric Boersma; Elke Bouwens; Roland R.J. van Kimmenade; Jolien W. Roos-Hesselink is a Medicine article available to read on EtoBox.
What is Novel Biomarkers Associated with Thoracic Aortic Disease about?
Background Biomarkers might help to improve diagnosis, surveillance and risk stratification of thoracic aortic disease (TAD). We explored the association between a broad spectrum of cardiovascular biomarkers with clinical characteristics and thoracic aortic diameter in TAD patients. Methods Venous blood-samples were obtained in 158 clinically stable TAD patients visiting our outpatient clinic (2017–2020). TAD was defined as a thoracic aortic diameter ≥ 40 mm, or genetic confirmation (hereditary TAD). The cardiovascular panel III of the Olink multiplex platform was used for batch analysis of 92 proteins. A comparison was made between biomarker levels in patients with and without previous aortic dissection and/or surgery, and with and without hereditary TAD. Linear regression analyses were applied to identify (relative, normalized) biomarker concentrations associated with the absolute thoracic aortic diameter (ADmax), and thoracic aortic diameter indexed for body surface area (IDmax). Results Median age of study patients was 61.0 (IQR 50.3–68.8) years, 37.3% females. Mean ADmax and IDmax were 43.3 ± 5.4 mm and 21.3 ± 3.3 mm/m2. After multivariable adjustment, Matrix Metalloproteinase
Who reads Novel Biomarkers Associated with Thoracic Aortic Disease?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Carlijn G.E. Thijssen; Silvy Dekker; Lidia R. Bons; Laurie W. Geenen; Arjen L. Gökalp; Johanna J.M. Takkenberg; Mostafa M. Mokhles; Jos A. Bekkers; Eric Boersma; Elke Bouwens; Roland R.J. van Kimmenade; Jolien W. Roos-Hesselink
- Publisher
- Elsevier BV
- Published
- 2023
- Language
- EN
- Field
- Medicine (Health Sciences)