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The document discusses the pathophysiology of acute pancreatitis. It describes acute pancreatitis as a disorder of intracellular calcium regulation in pancreatic cells that can trigger local and systemic complications. It then outlines the pathophysiology in 4 phases: 1) intracellular phase involving calcium dysregulation and organelle damage, 2) intra-acinar phase of zymogen activation causing oxidative stress and necrosis, 3) pancreatic phase of cytokine release and immune cell infiltration perpetuating i

Author

César Augusto Reyes García

Language

EN