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The leader peptide of a human rec. MnSOD as molecular carrier which delivers high amounts of Cisplatin into tumor cells inducing a fast apoptosis in vitro by Antonella Borrelli; Antonietta Schiattarella; Roberto Mancini; Franco Morelli; Clemente Capasso; Viviana De Luca; Enrico Gori; Aldo Mancini is a Medicine article available to read on EtoBox.
What is The leader peptide of a human rec. MnSOD as molecular carrier which delivers high amounts of Cisplatin into tumor cells inducing a fast apoptosis in vitro about?
## Abstract The leader peptide of a recombinant MnSOD (rMnSOD‐Lp) constitutes the carrier that allows rMnSOD to penetrate tumor cells. A synthetic preparation of rMnSOD‐Lp was ^68^Ga labeled (rMnSOD‐Lp‐^68^Ga) and injected into animals bearing spontaneous mammary cancers, followed by PET examinations, which demonstrated unambiguously the tumor sites in all the animals, suggesting that if rMnSOD‐Lp was able to transport the radioisotope into tumor cells, it would also be able to deliver cytotoxic molecules. The rMnSOD‐Lp was, therefore, conjugated to cisplatin (rMnSOD‐Lp‐CC) and added to cultured tumor cells. Equal concentrations of cisplatin were used for the tests. After treating the ovarian cancer cells with 11.1 μg of cisplatin alone, analysis by atomic absorbance spectrophotometry was able to detect only 6 ng of platinum, whereas when the same cells were treated with the same amount of cisplatin conjugated to leader peptide rMnSOD, 387 ng of platinum were detected, __i.e__., an amount 80 times greater. Only the tumor cells died following treatment with rMnSOD‐Lp‐CC; molecular analysis revealed that its addition generated an increasing expression of __Erk‐2__ and __Bax__ product
Who reads The leader peptide of a human rec. MnSOD as molecular carrier which delivers high amounts of Cisplatin into tumor cells inducing a fast apoptosis in vitro?
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- Author
- Antonella Borrelli; Antonietta Schiattarella; Roberto Mancini; Franco Morelli; Clemente Capasso; Viviana De Luca; Enrico Gori; Aldo Mancini
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Test accounts (ISSN 0020-7136)
- Published
- 2010
- Language
- EN
- Field
- Medicine (Health Sciences)