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The study investigates the antimicrobial properties of natural and semisynthetic butyrolactones derived from the marine fungus Aspergillus terreus against MRSA. Two natural butyrolactones were isolated, and semisynthetic analogues were created, with one analogue showing significant antimicrobial activity against MRSA with a MIC below 3 µM. Molecular docking studies indicated that these compounds bind effectively to the Mur-B enzyme, which is crucial for bacterial survival.
- Author
- omichar025
- Language
- EN