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High expression of cytochrome P450 2a-5 (coumarin 7-hydroxylase) in mouse hepatomas by Valery Kobliakov; Ludmila Kulikova; Dimitri Samoilov; Matti A. Lang is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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## Abstract A high level of Cyp2a‐5 was found in spontaneous and transplanted mouse hepatomas compared with normal liver. Increased expression of Cyp2a‐5 was associated with an increase in coumarin 7‐hydroxylation, a marker activity of Cyp2a‐5, and the corresponding mRNA, suggesting that regulation of Cyp2a‐5 in hepatomas is pretranslational. In contrast, the total P450 content and arylhydrocarbon hydroxylase and amidopyrene demethylase activities decreased. Pyrazole, a strong inducer of Cyp2a‐5 in normal mouse livers, also increases this isozyme in hepatomas. A parallel increase in the corresponding mRNA suggests that pyrazole, like the formation of hepatomas, affects the regulation of Cyp2a‐5 pretranslationally.

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Author

Valery Kobliakov; Ludmila Kulikova; Dimitri Samoilov; Matti A. Lang

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0899-1987)

Published

1993

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)