Can I read Estimation of 5-Fluorouracil-loaded Ethylene-vinyl Acetate Stent Coating Based on Percolation Thresholds on EtoBox?

Estimation of 5-Fluorouracil-loaded Ethylene-vinyl Acetate Stent Coating Based on Percolation Thresholds by Qing-hai Guo; Sheng-rong Guo; Zhong-min Wang is a Pharmacology, Toxicology and Pharmaceutics article available to read on EtoBox.

What is Estimation of 5-Fluorouracil-loaded Ethylene-vinyl Acetate Stent Coating Based on Percolation Thresholds about?

The drug percolation thresholds of 5-fluorouracil-loaded ethylene-vinyl acetate stent coatings were estimated to characterize their drug release behavior and mechanical properties. The stent coatings were prepared using 5-fluorouracil (5-FU) as antitumor drug and ethylene-vinyl acetate (EVA) as matrix forming material in different ratios. In vitro release assays were carried out exposing only one side of coating to pH 6.5 PBS. Based on the release profiles, the drug percolation thresholds were estimated as 0.21 of total porosity (corresponding to ca. 32%, w/w of the drug), which is in approximately agreement with the atomic force microscopy (AFM) result. Based on the coating tensible break strength and tear break strength data, the mechanical percolation thresholds of drug were obtained as 39.7+/-0.3 and 37.5+/-1.4% (w/w) of drug content, respectively.

Who reads Estimation of 5-Fluorouracil-loaded Ethylene-vinyl Acetate Stent Coating Based on Percolation Thresholds?

Author

Qing-hai Guo; Sheng-rong Guo; Zhong-min Wang

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0378-5173)

Published

2007

Language

EN

Field

Pharmacology, Toxicology and Pharmaceutics (Life Sciences)