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Can I read Mononuclear metal complexes with ciprofloxacin: Synthesis, characterization and DNA-binding properties on EtoBox?
Mononuclear metal complexes with ciprofloxacin: Synthesis, characterization and DNA-binding properties by George Psomas is a Chemistry article available to read on EtoBox.
What is Mononuclear metal complexes with ciprofloxacin: Synthesis, characterization and DNA-binding properties about?
Five novel metal complexes of the quinolone antibacterial agent ciprofloxacin with Mn 2+ , Fe 3+ , Co 2+ , Ni 2+ and MoO 2þ 2 have been prepared and characterized with physicochemical, spectroscopic and electrochemical techniques. In all these complexes, ciprofloxacin acts as a bidentate deprotonated ligand bound to the metal through the pyridone oxygen and one carboxylate oxygen. The central metal in each complex is six-coordinate and a slightly distorted octahedral geometry is proposed. The lowest energy model structures of the Mn 2+ , Fe 3+ and MoO 2þ 2 complexes have been determined with molecular modeling calculations. The cyclic voltammograms of the complexes have been recorded in dmso solution and in 1/2 dmso/buffer (containing 150 mM NaCl and 15 mM trisodium citrate at pH 7.0) solution and the corresponding redox potentials have been estimated. The biological activity of the complexes has been evaluated by examining their ability to bind to calf-thymus DNA (CT DNA) with UV and fluorescence spectroscopies and cyclic voltammetry. UV studies of the interaction of the complexes with DNA have shown that these compounds can bind to CT DNA. The binding constants of the complexes w
Who reads Mononuclear metal complexes with ciprofloxacin: Synthesis, characterization and DNA-binding properties?
It is typically read by researchers, students, and practitioners in Chemistry.
- Author
- George Psomas
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 0162-0134)
- Published
- 2008
- Language
- EN
- Field
- Chemistry (Physical Sciences)