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Can I read Sotatercept for the Treatment of Pulmonary Arterial Hypertension on EtoBox?
Sotatercept for the Treatment of Pulmonary Arterial Hypertension by Marc Humbert; Vallerie McLaughlin; J. Simon R. Gibbs; Mardi Gomberg-Maitland; Marius M. Hoeper; Ioana R. Preston; Rogerio Souza; Aaron Waxman; Pilar Escribano Subias; Jeremy Feldman; Gisela Meyer; David Montani; Karen M. Olsson; Solaiappan Manimaran; Jennifer Barnes; Peter G. Linde; Janethe de Oliveira Pena; David B. Badesch is a Medicine article available to read on EtoBox.
What is Sotatercept for the Treatment of Pulmonary Arterial Hypertension about?
## Background: Pulmonary arterial hypertension is characterized by pulmonary vascular remodeling, cellular proliferation, and poor long-term outcomes. dysfunctional bone morphogenetic protein pathway signaling is associated with both hereditary and idiopathic subtypes. sotatercept, a novel fusion protein, binds activins and growth differentiation factors in the attempt to restore balance between growth-promoting and growth-inhibiting signaling pathways. ## Methods: In this 24-week multicenter trial, we randomly assigned 106 adults who were receiving background therapy for pulmonary arterial hypertension to receive subcutaneous sotatercept at a dose of 0.3 mg per kilogram of body weight every 3 weeks or 0.7 mg per kilogram every 3 weeks or placebo. the primary end point was the change from baseline to week 24 in pulmonary vascular resistance. ## Results: Baseline characteristics were similar among the three groups. the least-squares mean difference between the sotatercept 0.3-mg group and the placebo group in the change from baseline to week 24 in pulmonary vascular resistance was -145.8 dyn · sec · cm (95% confidence interval [ci], -241.0 to -50.6; p = 0.003). the least-squares mea
Who reads Sotatercept for the Treatment of Pulmonary Arterial Hypertension?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Marc Humbert; Vallerie McLaughlin; J. Simon R. Gibbs; Mardi Gomberg-Maitland; Marius M. Hoeper; Ioana R. Preston; Rogerio Souza; Aaron Waxman; Pilar Escribano Subias; Jeremy Feldman; Gisela Meyer; David Montani; Karen M. Olsson; Solaiappan Manimaran; Jennifer Barnes; Peter G. Linde; Janethe de Oliveira Pena; David B. Badesch
- Publisher
- Massachusetts Medical Society
- Published
- 2021
- Language
- EN
- Field
- Medicine (Health Sciences)