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P719Endothelial expression of adenylate cyclase type 9 (Adcy9) regulates endothelial cell signalling and vasodilation by Y Rautureau; M Berlatie; D Rivas; K Uy; G Miquel; M E Higgins; A Nault; D Rhainds; E Thorin; J Ledoux; E Rheaume; J C Tardif is a Medicine article available to read on EtoBox.

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## Abstract ## Background/Introduction The clinical benefits of the cholesterol ester transfer protein (CETP) inhibitor dalcetrapib are dependent on the ADCY9 gene, which encodes adenylate cyclase (AC) type 9 (AC9). AC9 is one of nine membrane-bound isoforms of AC producing cyclic adenosine monophosphate (cAMP). We demonstrated that Adcy9 inactivation in the mouse protects from atherosclerosis, but only in absence of CETP. Adcy9 inactivation is also associated with improved endothelial function, including greater endothelial-dependent vasodilation (EDV) in response to acetylcholine (ACh). This suggests that Adcy9 may control endothelial Ca2+, an essential mediator of endothelial cell (EC) signalling. We hypothesized that Adcy9 is expressed in the endothelium and controls EC signalling. ## Purpose Our aim was to study AC9 expression in the vascular endothelium and the role of AC9 expression on endothelial cAMP signalling and Ca2+ dynamics. ## Methods The effects of Adcy9 inactivation were studied using wild-type (WT) and Adcy9-inactivated (Adcy9Gt/Gt) mice and siRNA-mediated inactivation of ADCY9 in human coronary artery endothelial cells (HCAEC). In the mouse, AC9 expression was qu

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Author

Y Rautureau; M Berlatie; D Rivas; K Uy; G Miquel; M E Higgins; A Nault; D Rhainds; E Thorin; J Ledoux; E Rheaume; J C Tardif

Publisher

Oxford University Press; Oxford University Press (OUP); Elsevier BV (ISSN 0195-668X)

Published

2019

Language

EN

Field

Medicine (Health Sciences)