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Can I read A Supramolecular Self‐Assembling Nanoagent by Inducing Intracellular Aggregation of PSMA for Prostate Cancer Molecularly Targeted Theranostics on EtoBox?
A Supramolecular Self‐Assembling Nanoagent by Inducing Intracellular Aggregation of PSMA for Prostate Cancer Molecularly Targeted Theranostics by Weijie Zhang; He Wang; Tianjiao Wang; Dan Ding; Jianquan Hou; Yang Shi; Yuhua Huang is a Engineering article available to read on EtoBox.
What is A Supramolecular Self‐Assembling Nanoagent by Inducing Intracellular Aggregation of PSMA for Prostate Cancer Molecularly Targeted Theranostics about?
Prostate cancer (PCa) with prostate-specific membrane antigen (PSMA)-specific high expression is well suited for molecularly targeted theranostics. PSMA expression correlates with the malignancy of PCa, and its dimeric form can promote tumor progression by exerting enzymatic activity to activate downstream signal transduction. However, almost no studies have shown that arresting the procancer signaling of the PSMA receptors themselves can cause tumor cell death. Meanwhile, supramolecular self-assembling peptides are widely used to design anticancer agents due to their unique and excellent properties. Here, a PSMA-targeting supramolecular self-assembling nano theranostic agent, DBT-2FFGACUPA, which actively targets PSMA receptors on PCa cell membranes and induces them to enter the cell and form large aggregates, is developed. This process not only selectively images PSMA-positive tumor cells but also suppresses the downstream procancer signals of PSMA, causing tumor cell death. This work provides an alternative approach and an advanced agent for molecularly targeted theranostics options in PCa that can induce tumor cell death without relying on any reported anticancer drugs.
Who reads A Supramolecular Self‐Assembling Nanoagent by Inducing Intracellular Aggregation of PSMA for Prostate Cancer Molecularly Targeted Theranostics?
It is typically read by researchers, students, and practitioners in Engineering.
- Author
- Weijie Zhang; He Wang; Tianjiao Wang; Dan Ding; Jianquan Hou; Yang Shi; Yuhua Huang
- Publisher
- Wiley
- Published
- 2022
- Language
- EN
- Field
- Engineering (Physical Sciences)