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Can I read VCAM1 Is Induced in Ovarian Theca and Stromal Cells in a Mouse Model of Androgen Excess on EtoBox?
VCAM1 Is Induced in Ovarian Theca and Stromal Cells in a Mouse Model of Androgen Excess by Nicholes R Candelaria; Achuth Padmanabhan; Fabio Stossi; M Cecilia Ljungberg; Katharine E Shelly; Braden K Pew; Minerva Solis; Ayane M Rossano; Jan M McAllister; Sheng Wu; JoAnne S Richards is a Medicine article available to read on EtoBox.
What is VCAM1 Is Induced in Ovarian Theca and Stromal Cells in a Mouse Model of Androgen Excess about?
Ovarian theca androgen production is regulated by the pituitary LH and intrafollicular factors. Enhanced androgen biosynthesis by theca cells contributes to polycystic ovary syndrome (PCOS) in women, but the ovarian consequences of elevated androgens are not completely understood. Our study documents the molecular events that are altered in the theca and stromal cells of mice exposed to high androgen levels, using the nonaromatizable androgen DHT. Changes in ovarian morphology and function were observed not only in follicles, but also in the stromal compartment. Genome-wide microarray analyses revealed marked changes in the ovarian transcriptome of DHT-treated females within 1 week. Particularly striking was the increased expression of vascular cell adhesion molecule 1 (Vcam1) specifically in the NR2F2/COUPTF-II lineage theca cells, not granulosa cells, of growing follicles and throughout the stroma of the androgen-treated mice. This response was mediated by androgen receptors (ARs) present in theca and stromal cells. Human theca-derived cultures expressed both ARs and NR2F2 that were nuclear. VCAM1 mRNA and protein were higher in PCOS-derived theca cells compared with control thec
Who reads VCAM1 Is Induced in Ovarian Theca and Stromal Cells in a Mouse Model of Androgen Excess?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Nicholes R Candelaria; Achuth Padmanabhan; Fabio Stossi; M Cecilia Ljungberg; Katharine E Shelly; Braden K Pew; Minerva Solis; Ayane M Rossano; Jan M McAllister; Sheng Wu; JoAnne S Richards
- Publisher
- Endocrine Society; The Endocrine Society; Oxford University Press; Oxford University Press (OUP) (ISSN 0013-7227)
- Published
- 2019
- Language
- EN
- Field
- Medicine (Health Sciences)