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Role of vitamin A elimination or supplementation diets during postnatal development on the allergic sensitisation in mice by Ralph Rühl; Andrej Hänel; Ada L. Garcia; Anja Dahten; Udo Herz; Florian J. Schweigert; Margitta Worm is a Medicine article available to read on EtoBox.

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## Abstract Vitamin A (VA) and its derivatives, the retinoids, are important factors for the development of the immune system. It has been shown in adult animals that proliferation of lymphocyte populations and antibody secretion are retinoid dependent, while little is known about the effects of retinoids during postnatal development. The aim of this study was to investigate the role of VA on allergic sensitisation during lactation and after weaning using an __in vivo__ system for postnatal allergic sensitisation in mice. Different VA diets (basal/VA elimination/VA (as retinyl palmitate) supplemented) were fed to the dams throughout lactation and directly to the pups after weaning. Allergic sensitisation was induced with a single peritoneal ovalbumin (OVA) injection at day 28 after weaning. The phenotype of lymphocytes was analysed by flow cytometry and functional data were obtained by analysis of (IL‐4/IFN‐γ) cytokine production and antibody production (OVA‐specific IgG1 and IgE) in the offspring. VA/retinyl palmitate supplementation during lactation and after weaning decreased CD3+, CD4+, CD8+ and B220+ populations in splenic lymphocytes but also significantly enhanced IL‐4 produ

Who reads Role of vitamin A elimination or supplementation diets during postnatal development on the allergic sensitisation in mice?

Author

Ralph Rühl; Andrej Hänel; Ada L. Garcia; Anja Dahten; Udo Herz; Florian J. Schweigert; Margitta Worm

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Ltd.; Wiley (ISSN 1613-4125)

Published

2007

Language

EN

Field

Medicine (Health Sciences)