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This research article focuses on the cloning and characterization of monoclonal antibodies (mAbs) from a patient with anti-NMDA receptor encephalitis (ANRE). The study identifies two distinct mAbs that bind to different epitopes on the GluN1 subunit of the NMDA receptor, demonstrating their effects on receptor internalization and voluntary locomotor activity in mice. These findings support the pathogenic role of anti-GluN1 antibodies in ANRE and provide insights into the underlying mechanisms of the disease

Author

jaquelinefundarpe

Language

EN