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Vaginotypes of the Human Vaginal Microbiome by Leonardo Mancabelli; Chiara Tarracchini; Christian Milani; Gabriele Andrea Lugli; Federico Fontana; Francesca Turroni; Douwe van Sinderen; Marco Ventura is a Environmental Science article available to read on EtoBox.

What is Vaginotypes of the Human Vaginal Microbiome about?

## Summary The human vaginal environment harbours a community of bacteria that plays an important role in maintaining vaginal health and in protecting this environment from various urogenital infections. This bacterial population, also known as vaginal microbiota, has been demonstrated to be dominated by members of the Lactobacillus genus. Several studies employing 16S rRNA gene‐based amplicon sequencing have classified the vaginal microbiota into five distinct community state types (CSTs) or vaginotypes. To deepen our understanding of the vaginal microbiota we performed an in‐depth meta‐analysis of 1312 publicly available datasets concerning healthy vaginal microbiome information obtained by metagenomics sequencing. The analysis confirmed the predominance of taxa belonging to the Lactobacillus genus, followed by members of the genera Gardnerella, Vibrio and Atopobium. Moreover, the statistical robustness offered by this meta‐analysis allowed us to disentangle the species‐level composition of dominant and accessory taxa constituting each vaginotype and to revisit and refine the previously proposed CST classification. In addition, a functional characterization of the metagenomic dat

Who reads Vaginotypes of the Human Vaginal Microbiome?

Author

Leonardo Mancabelli; Chiara Tarracchini; Christian Milani; Gabriele Andrea Lugli; Federico Fontana; Francesca Turroni; Douwe van Sinderen; Marco Ventura

Publisher

Wiley

Published

2021

Language

EN

Field

Environmental Science (Physical Sciences)