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Fluorimetric Determination of Maprotiline in Urine and Plasma After Thin-layer Chromatographic Separation by Monika Prinoth; Ernst Mutschler is a Chemistry article available to read on EtoBox.

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Maprotiline {LudiomiP , Ciba-Geigy; N-methyl-[ 3-(9,10-ethanoanthraceneg( lOH)-yl)-propyl] aminhydrochloride } is a widely used antidepressive agent. several methods for the detection of maprotiline in plasma and urine have already been developed. Riess [l] determined maprotiline by a double-radioisotope derivative technique. Since not every laboratory is equipped with the corresponding instrumentation, a gas-liquid chromatographic method for estimating maprotiline was suggested by Geiger et al. [ 21. This procedure involves a re-extraction step and the formation of a derivative, both of which are rather time-consuming. Further gas chromatographic methods for the determination of maprotiline have been introduced by Gupta et al. [3], Sioufi and Richard [ 41, Charette et al. [ 51, and K&kkIinen and SeppiilZ [6]. For compliance studies it seemed desirable to our group to find a simple and rapid procedure for the quantitative measurement of maprotiline. The method we developed consists of four steps: (1) extraction from an alkaline sample with n-heptane-isopropanol (99:l); (2) derivatization with NBD chloride (7-chloro-4Initrobenzbfurazan);' (3) separation of from urine or plasma const

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Author

Monika Prinoth; Ernst Mutschler

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0378-4347)

Published

1984

Language

EN

Field

Chemistry (Physical Sciences)