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Bowel symptoms predate the diagnosis among many patients with multiple sclerosis: A 14‐year cohort study by Mariana N. Almeida; Casey Silvernale; Braden Kuo; Kyle Staller is a Medicine article available to read on EtoBox.

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## Abstract ## Background Multiple sclerosis (MS) is an autoimmune, neurodegenerative disease frequently complicated by bowel symptoms. Multiple sclerosis typically first manifests with a demyelination event, also known as a clinically isolated syndrome (CIS). We sought to examine the prevalence of prodromal bowel symptoms predating a CIS in patients with MS as part of a recently characterized prodromal phase of disease. ## Methods We constructed a retrospective cohort of MS patients with bowel symptoms and an identifiable CIS at two tertiary care centers over 14 years using administrative and billing data. We determined the date of onset of reported bowel symptoms in comparison with the date of first CIS and determined the overall prevalence of prediagnosis bowel symptoms within 1, 2, 3, and >3 years from a CIS. We used multivariable modeling to determine demographic and clinical risk factors for prediagnosis bowel symptoms. ## Key Results Among 385 MS patients with reported bowel symptoms, 122 (31.6%) reported bowel symptoms prior to CIS. The most common first bowel symptom was constipation (50.0%), followed by diarrhea (29.5%). The average lead time between a first bowel symptom

Who reads Bowel symptoms predate the diagnosis among many patients with multiple sclerosis: A 14‐year cohort study?

Author

Mariana N. Almeida; Casey Silvernale; Braden Kuo; Kyle Staller

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 1350-1925)

Published

2019

Language

EN

Field

Medicine (Health Sciences)