Can I read Both exogenous and endogenous interleukin-10 affects the maturation of bone-marrow-derived dendritic cells in vitro and strongly influences T-cell priming in vivo on EtoBox?

Both exogenous and endogenous interleukin-10 affects the maturation of bone-marrow-derived dendritic cells in vitro and strongly influences T-cell priming in vivo by Claus Haase; Trine N. Jørgensen; Birgitte K. Michelsen is a Immunology and Microbiology article available to read on EtoBox.

What is Both exogenous and endogenous interleukin-10 affects the maturation of bone-marrow-derived dendritic cells in vitro and strongly influences T-cell priming in vivo about?

## Summary In order to avoid autoimmunity and excessive tissue destruction, the action of certain immunoinhibitory substances are very important for negative regulation of the immune system. Interleukin‐10 (IL‐10) is an important immunoregulatory cytokine which is thought to negatively affect both T cells and antigen‐presenting cells __in vivo__. Adoptive transfer of IL‐10‐treated bone‐marrow‐derived dendritic cells (BMDCs) may be one therapeutic avenue to inhibit autoimmunity. In this study we present a comprehensive analysis of the effects of IL‐10 on murine BMDC. We demonstrate that IL‐10 can prevent BMDC maturation, as measured by both cytokine production and T‐cell priming capacity __in vitro__. Furthermore, we show that IL‐10 can inhibit DC maturation induced by strong stimulatory signals such as lipopolysaccharide or a mixture of cytokines (interferon‐γ, tumour necrosis factor‐α, IL‐4). Interestingly, maturation of both T helper 1‐ and T helper 2‐inducing DCs, characterized by the induction of high levels of interferon‐γ and IL‐4‐production by responding T cells, respectively, was inhibited by IL‐10 __in vitro__. Finally, our data suggest that both endogenous and exogenous I

Who reads Both exogenous and endogenous interleukin-10 affects the maturation of bone-marrow-derived dendritic cells in vitro and strongly influences T-cell priming in vivo?

Author

Claus Haase; Trine N. Jørgensen; Birgitte K. Michelsen

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0019-2805)

Published

2002

Language

EN

Field

Immunology and Microbiology (Life Sciences)