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Depressive symptoms were a common risk factor for pre-frailty and frailty in patients with Alzheimer’s disease by Wu, Yu Hsuan; Lee, Hsin Ning; Chang, Yu San; Wu, Chiu Hsiang; Wang, Chin Jen is a Medicine article available to read on EtoBox.

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## Objectives: This study aimed to investigate factors associated with frailty in patients with mild to moderate alzheimer's disease (ad). ## Methods: One hundred fifty-seven outpatients aged 65 years or older with mild to moderate ad were enrolled from january 2018 to december 2018. cognitive status, depressive mood, activities of daily livings (adls), body mass index, handgrip strength (hgs), usual gait speed (ugs), and serum levels of 25-hydroxyvitamin d, hemoglobin (hb), albumin, and creatinine were assessed. frailty was defined as a clinical syndrome in which three or more of the following criteria were present: fatigue, resistance, ambulation, illness, and unintentional weight loss. ## Results: The prevalence of frailty was 15.9%. those classified as being frail were significantly older, had worse cognitive function, worse adls, slower ugs, and lower level of hb compared to those classified as being pre-frail and those robust, respectively. the pre-frail group was significantly older, had worse adls, and slower ugs compared to the robust group. both the frail and pre-frail groups had more depressive symptoms and weaker hgs than the robust group. multiple logistic regression a

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Author

Wu, Yu Hsuan; Lee, Hsin Ning; Chang, Yu San; Wu, Chiu Hsiang; Wang, Chin Jen

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0167-4943)

Published

2020

Language

EN

Field

Medicine (Health Sciences)