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Genetic Profiles Correlate With Clinical Outcomes in Squamous Cell Carcinoma of Head and Neck by S.R. Nandalur; D. Krauss; P. Chen; K. Lorenc; K. Nilsson; J. Resau; B. Teh; J. Zhang; A. Martinez; J. Akervall is a Medicine article available to read on EtoBox.

What is Genetic Profiles Correlate With Clinical Outcomes in Squamous Cell Carcinoma of Head and Neck about?

Purpose/Objective(s): Degree of response to radiotherapy (RT) and chemoradiotherapy (CRT) differs amongst head and neck cancer patients. This has previously been correlated with c-DNA microarray studies showing five markers predictive of chemosensitivity and radiosensitivity (VEGF, Cmet, and Yap1). We aimed to correlate expression of these markers in pre-treatment biopsies with clinical outcomes in patients with squamous carcinoma of the head and neck (SCCHN). Materials/Methods: From December 1995 to November 2004, 86 patients with clinical stage II-IVa oropharyngeal (n = 30) and stage I-IVa laryngeal (n = 56) SCCHN who underwent treatment with either RT alone (n = 47) or CRT (n = 39) were selected for analysis. RT was delivered using 3-D conformal RT or intensity modulated RT to a median dose 7000 cGy (2400 cGy-8160 cGy) and concurrent cisplatinum-based chemotherapy. Treatment response was evaluated during and after treatment using nasopharyngoscopy, computed tomography, and/or biopsies. Any locoregional recurrence within 6 months after completion of radiation therapy was considered an incomplete response defined as either a partial response or no response. Immunohistochemical sta

Who reads Genetic Profiles Correlate With Clinical Outcomes in Squamous Cell Carcinoma of Head and Neck?

Author

S.R. Nandalur; D. Krauss; P. Chen; K. Lorenc; K. Nilsson; J. Resau; B. Teh; J. Zhang; A. Martinez; J. Akervall

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0360-3016)

Published

2007

Language

EN

Field

Medicine (Health Sciences)