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Effects of mGlu1-receptor blockade on ethanol self-administration in inbred alcohol-preferring rats by J. Besheer; S. Faccidomo; J.J.M. Grondin; C.W. Hodge is a Medicine article available to read on EtoBox.

What is Effects of mGlu1-receptor blockade on ethanol self-administration in inbred alcohol-preferring rats about?

The Group I family of metabotropic glutamate receptors includes subtype 1 (mGlu1) and subtype 5 (mGlu5) receptors. This family of receptors has generated interest as potential targets for different areas of therapeutic development, including intervention for alcohol and drug abuse. Most of this interest is driven by findings showing involvement of mGlu5 receptors in the regulation of drug self-administration; however, studies examining the role of mGlu1 receptors in drug self-administration are limited. The purpose of this work was to examine the role of mGlu1-receptor antagonism in the maintenance of ethanol self-administration and the self-administration of an alternate nondrug reward, sucrose. Male alcohol-preferring inbred rats were trained to self-administer ethanol (15% vol/vol) versus water on a concurrent schedule of reinforcement, and the effect of the mGlu1-receptor antagonist JNJ16259685 (0.1-1.0mg/kg intraperitoneal [IP]) was evaluated on self-administration. The rats were then trained to self-administer sucrose (0.4% wt/vol) versus water, and the same dose range of JNJ16259685 was tested. Locomotor activity was tested in a separate assessment to evaluate potential nons

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Author

J. Besheer; S. Faccidomo; J.J.M. Grondin; C.W. Hodge

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0741-8329)

Published

2008

Language

EN

Field

Medicine (Health Sciences)