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Can I read Translational development of ABCB5+ dermal mesenchymal stem cells for therapeutic induction of angiogenesis in non-healing diabetic foot ulcers on EtoBox?
Translational development of ABCB5+ dermal mesenchymal stem cells for therapeutic induction of angiogenesis in non-healing diabetic foot ulcers by Andreas Kerstan; Kathrin Dieter; Elke Niebergall-Roth; Sabrina Klingele; Michael Jünger; Christoph Hasslacher; Georg Daeschlein; Lutz Stemler; Ulrich Meyer-Pannwitt; Kristin Schubert; Gerhard Klausmann; Titus Raab; Matthias Goebeler; Korinna Kraft; Jasmina Esterlechner; Hannes M. Schröder; Samar Sadeghi; Seda Ballikaya; Martin Gasser; Ana M. Waaga-Gasser; George F. Murphy; Dennis P. Orgill; Natasha Y. Frank; Christoph Ganss; Karin Scharffetter-Kochanek; Markus H. Frank; Mark A. Kluth is a Medicine article available to read on EtoBox.
What is Translational development of ABCB5+ dermal mesenchymal stem cells for therapeutic induction of angiogenesis in non-healing diabetic foot ulcers about?
## Abstract ## Background While rapid healing of diabetic foot ulcers (DFUs) is highly desirable to avoid infections, amputations and life-threatening complications, DFUs often respond poorly to standard treatment. GMP-manufactured skin-derived ABCB5^+^ mesenchymal stem cells (MSCs) might provide a new adjunctive DFU treatment, based on their remarkable skin wound homing and engraftment potential, their ability to adaptively respond to inflammatory signals, and their wound healing-promoting efficacy in mouse wound models and human chronic venous ulcers. ## Methods The angiogenic potential of ABCB5^+^ MSCs was characterized with respect to angiogenic factor expression at the mRNA and protein level, in vitro endothelial trans-differentiation and tube formation potential, and perfusion-restoring capacity in a mouse hindlimb ischemia model. Finally, the efficacy and safety of ABCB5^+^ MSCs for topical adjunctive treatment of chronic, standard therapy-refractory, neuropathic plantar DFUs were assessed in an open-label single-arm clinical trial. ## Results Hypoxic incubation of ABCB5^+^ MSCs led to posttranslational stabilization of the hypoxia-inducible transcription factor 1α (HIF-1α)
Who reads Translational development of ABCB5+ dermal mesenchymal stem cells for therapeutic induction of angiogenesis in non-healing diabetic foot ulcers?
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- Author
- Andreas Kerstan; Kathrin Dieter; Elke Niebergall-Roth; Sabrina Klingele; Michael Jünger; Christoph Hasslacher; Georg Daeschlein; Lutz Stemler; Ulrich Meyer-Pannwitt; Kristin Schubert; Gerhard Klausmann; Titus Raab; Matthias Goebeler; Korinna Kraft; Jasmina Esterlechner; Hannes M. Schröder; Samar Sadeghi; Seda Ballikaya; Martin Gasser; Ana M. Waaga-Gasser; George F. Murphy; Dennis P. Orgill; Natasha Y. Frank; Christoph Ganss; Karin Scharffetter-Kochanek; Markus H. Frank; Mark A. Kluth
- Publisher
- Springer Science and Business Media LLC
- Published
- 2022
- Language
- EN
- Field
- Medicine (Health Sciences)