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Tumor size improves the accuracy of the prognostic prediction of T4a stage colon cancer by Yuexiang Liang; Qiang Li; Donglei He; Yong Chen; Jingquan Li is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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The aim of this study was to evaluate the potential impact of tumor size on the long-term outcome of colon cancer (CC) patients after curative surgery. A total of 782 curatively resected T4a stage CC patients without distant metastasis were enrolled. Patients were categorized into 2 groups according to the best threshold of tumor size: larger group (LG) and smaller group (SG). Propensity score matching was used to adjust for the differences in baseline characteristics. The ideal cutoff point of tumor size was 5 cm. In the multivariate analysis for the whole study series, tumor size was an independent prognostic factor. Patients in the LG had significant lower 5-year overall survival (OS) and relapse-free survival (RFS) rates (OS: 63.5% versus 75.2%, __P__ < 0.001; RFS: 59.5% versus 72.4%, __P__ < 0.001) than those in the SG. After matching, patients in the LG still demonstrated significant lower 5-year OS and RFS rates than those in the SG. The modified tumor-size-node-metastasis (mTSNM) staging system including tumor size was found to be more appropriate for predicting the OS and RFS of T4a stage CC than TNM stage, and the -2log likelihood of the mTSNM staging system was smaller t

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Author

Yuexiang Liang; Qiang Li; Donglei He; Yong Chen; Jingquan Li

Publisher

Springer Science and Business Media LLC

Published

2021

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)