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Cancer Patients’ Return-to-work Adaptation Experience and Coping Resources: a Grounded Theory Study by Jiashuo Xu; Yuwen Zhou; Jiamei Li; Jue Tang; Xiaoyun Hu; Yifan Chen; Yujie Guo is a Health Professions article available to read on EtoBox.

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## Abstract ## Background The aim of this study was to evaluate the efficacy and safety of osimertinib for the treatment of leptomeningeal metastases (LM) from epidermal growth factor receptor (EGFR)-mutant non-small cell lung cancer (NSCLC). ## Methods We conducted a systematic review and meta-analysis to aggregate the clinical outcomes of patients with LM from EGFR-mutant NSCLC treated with osimertinib. A comprehensive literature search for published and unpublished studies was implemented in April 2021 of PubMed, EMBASE, the Cochrane Library, and several international conference databases, in accordance with the PRISMA guidelines. Meta-analysis of proportions was conducted to calculate the pooled rate of overall response rate (ORR), disease control rate (DCR), one-year overall survival (OS), and adverse events (AEs). ## Results A total of eleven studies (five prospective and six retrospective) including 353 patients were included. The majority of patients (346/353, 98.0%) received osimertinib as ≥ 2nd-line treatment for LM, either at a dosage of 80 mg (161/353, 45.6%) or 160 mg (191/353, 54.1%). The pooled rates of ORR and DCR were 42% (95% CI 24% to 59%) and 93% (95% CI 88% to

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Author

Jiashuo Xu; Yuwen Zhou; Jiamei Li; Jue Tang; Xiaoyun Hu; Yifan Chen; Yujie Guo

Publisher

Springer Science and Business Media LLC

Published

2023

Language

EN

Field

Health Professions (Health Sciences)