Can I read Desmopressin in Elderly Patients with Nocturia: Short-term Safety and Effects on Urine Output, Sleep and Voiding Patterns on EtoBox?

Desmopressin in Elderly Patients with Nocturia: Short-term Safety and Effects on Urine Output, Sleep and Voiding Patterns by A. Rembratt; J.P. Norgaard; K-E. Andersson is a Medicine article available to read on EtoBox.

What is Desmopressin in Elderly Patients with Nocturia: Short-term Safety and Effects on Urine Output, Sleep and Voiding Patterns about?

## OBJECTIVE To investigate the short‐term safety of desmopressin in elderly patients with nocturia, with special focus on the risk of hyponatraemia, and to assess the short‐term effects on urine output, sleep and voiding patterns. ## PATIENTS AND METHODS Patients (72) were recruited from a study using frequency‐volume charts, which in turn was preceded by a questionnaire study. Each patient took one 0.2 mg desmopressin tablet at bedtime for three consecutive nights and kept a frequency‐volume chart. Serum sodium was assessed in the morning after the first and the third dose. Patients with a mean serum sodium level during treatment deviating more than five units from baseline were considered sensitive to change in serum sodium. Potential predictors for sodium sensitivity and response were investigated with logistic and multiple regression. ## RESULTS All 72 enrolled patients completed the trial; no serious adverse events occurred and no adverse events of severe intensity were recorded. Six patients were sensitive to change in serum sodium. The risk (odds ratio, 95% confidence interval) increased with increasing age (1.3, 1.1–1.6), concomitant cardiac disease (10.0, 0.9–105.8) and i

Who reads Desmopressin in Elderly Patients with Nocturia: Short-term Safety and Effects on Urine Output, Sleep and Voiding Patterns?

Author

A. Rembratt; J.P. Norgaard; K-E. Andersson

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 1464-4096)

Published

2003

Language

EN

Field

Medicine (Health Sciences)