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Can I read Methylphenidate Use in Children and Risk of Cancer at 18 Sites: Results of Surveillance Analyses on EtoBox?
Methylphenidate Use in Children and Risk of Cancer at 18 Sites: Results of Surveillance Analyses by Nina Oestreicher; Gary D. Friedman; Sheng-Fang Jiang; Jim Chan; Charles Quesenberry Jr; Laurel A. Habel is a Medicine article available to read on EtoBox.
What is Methylphenidate Use in Children and Risk of Cancer at 18 Sites: Results of Surveillance Analyses about?
## Abstract ## Purpose A recent report linked methylphenidate (MPH) use in children to cytologic abnormalities in plasma lymphocytes, a possible cancer biomarker. The purpose of this study was to investigate the association of MPH use and childhood cancer risk. ## Methods Using automated pharmacy databases and the SEER‐affiliated cancer registry of the Kaiser Permanente Medical Care Program (KPMCP), we compared cancer rates at 18 sites among 35 400 MPH users who received it before age 20 to rates among KPMCP membership (age, sex, and calendar year standardized). Medical records of MPH exposed cancer cases were reviewed to identify the presence of established risk factors. ## Results There were 23 cancers among MPH users, __versus__ 20.4 expected (standardized morbidity ratio, SMR = 1.13, 95% confidence interval (0.72, 1.70)). Given the small number of cancers, site‐specific SMR estimates were imprecise. Only one SMR was statistically significant at the __p__ < 0.05 level, which given the number of comparisons is consistent with the absence of a true association at any site. MPH use was associated with increased risk of lymphocytic leukemia (SMR = 2.64 (1.14, 5.20)), based on eight
Who reads Methylphenidate Use in Children and Risk of Cancer at 18 Sites: Results of Surveillance Analyses?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Nina Oestreicher; Gary D. Friedman; Sheng-Fang Jiang; Jim Chan; Charles Quesenberry Jr; Laurel A. Habel
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1053-8569)
- Published
- 2007
- Language
- EN
- Field
- Medicine (Health Sciences)