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HPA axis activity in multiple sclerosis correlates with disease severity, lesion type and gene expression in normal-appearing white matter by Jeroen Melief; Stella J. de Wit; Corbert G. van Eden; Charlotte Teunissen; Jörg Hamann; Bernard M. Uitdehaag; Dick Swaab; Inge Huitinga is a Medicine article available to read on EtoBox.
What is HPA axis activity in multiple sclerosis correlates with disease severity, lesion type and gene expression in normal-appearing white matter about?
suggesting that neurodegeneration is a strong determinant of HPA axis activity. High cortisol levels were associated with slower disease progression, especially in females with secondary progressive MS. Patients with low cortisol levels had greater numbers of active lesions and tended towards having less remyelinated plaques than patients with high cortisol levels. Interestingly, NAWM of patients with high cortisol levels displayed elevated expression of glucocorticoid-responsive genes, such as CD163, and decreased expression of pro-inflammatory genes, such as tumor necrosis factor-α. Thus, HPA axis hyperactivity in MS coincides with low inflammation and/or high neurodegeneration, and may impact on lesion pathology and molecular mechanisms in NAWM and thereby be of great importance for suppression of disease activity.
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It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Jeroen Melief; Stella J. de Wit; Corbert G. van Eden; Charlotte Teunissen; Jörg Hamann; Bernard M. Uitdehaag; Dick Swaab; Inge Huitinga
- Publisher
- Springer Science and Business Media LLC
- Published
- 2013
- Language
- EN
- Field
- Medicine (Life Sciences)