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The ramC gene is required for morphogenesis in Streptomyces coelicolor and expressed in a cell type-specific manner under the direct control of RamR by Tamara J. O'Connor; Pamela Kanellis; Justin R. Nodwell is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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## Summary The bacterium __Streptomyces coelicolor__ produces two cell types during the course of its life cycle: the aerial hyphae, which metamorphose into spores, and the substrate hyphae, which synthesize antibiotics. We show that the genes __ramC__ and __ramR__ are required for the production of the aerial hyphae but are dispensable for vegetative growth and antibiotic synthesis. We find that __ramC__ is expressed in the substrate hyphae and shut off in the aerial hyphae by the time visible signs of sporulation‐associated septation are evident. Production of RamC requires the developmental regulators __bldD, cprA__ and __ramR__, but not __bldM__ or __bldN__, and we show that the RamR protein interacts directly with DNA in the __ramC__ promoter region sug‐gesting that it is, at least in part, responsible for regulating __ramC__ expression.

Who reads The ramC gene is required for morphogenesis in Streptomyces coelicolor and expressed in a cell type-specific manner under the direct control of RamR?

Author

Tamara J. O'Connor; Pamela Kanellis; Justin R. Nodwell

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0950-382X)

Published

2002

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)