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Liver disease activity and hepatitis B virus replication in chronic delta antigen-positive hepatitis B virus carriers by Stephanos J. Hadziyannis; Morris Sherman; Harvey M. Lieberman; David A. Shafritz is a Medicine article available to read on EtoBox.

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Delta antigen is currently thought to reflect superinfection of the liver with a defective RNA virus (delta agent), requiring helper function from hepatitis B virus for its replication. To assess the influence of delta agent on hepatitis B virus replication in patients persistently infected with both viruses and showing chronic liver disease, we measured serum and liver hepatitis B virus DNA in HBsAg-positive chronic liver disease patients who were either positive or negative for delta antigen in the liver. Hepatitis B virus DNA was assayed in the serum of 21 patients with delta antigen-positive/HBsAg-positive chronic liver disease and in 2 1 patients with delta antigennegative/HBsAg-positive chronic liver disease matched for HBeAg/anti-HBe status and underlying liver histology. HBcAg and delta antigen in liver was determined by immunofluorescence or immunoperoxidase staining. In delta antigen-positive/HBsAg-positive chronic liver disease, serum hepatitis B virus DNA was detected transiently in 4 of 21 cases (19%) and was present in these patients at low levels (trace to 2+). In contrast, 9 of 21 (43%) delta antigen-negative/HBsAgpositive chronic liver disease patients were serum h

Who reads Liver disease activity and hepatitis B virus replication in chronic delta antigen-positive hepatitis B virus carriers?

Author

Stephanos J. Hadziyannis; Morris Sherman; Harvey M. Lieberman; David A. Shafritz

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Elsevier BV; Wiley; Research Square (ISSN 0270-9139)

Published

1985

Language

EN

Field

Medicine (Health Sciences)