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Can I read Requirement of the IFN‐α/β‐induced CXCR3 chemokine signalling for CD8^+^ T cell activation on EtoBox?
Requirement of the IFN‐α/β‐induced CXCR3 chemokine signalling for CD8^+^ T cell activation by Kouetsu Ogasawara; Shigeaki Hida; Youmin Weng; Akio Saiura; Kojiro Sato; Hiroshi Takayanagi; Shinya Sakaguchi; Taeko Yokochi; Tatsuhiko Kodama; Makoto Naitoh; Julie A. De Martino; Tadatsugu Taniguchi is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Requirement of the IFN‐α/β‐induced CXCR3 chemokine signalling for CD8^+^ T cell activation about?
## Abstract **Background:** Activation of both CD4^+^ T and CD8^+^ T cells is triggered by the engagement of the T cell antigen receptor (TCR) with MHC/peptide complexes on antigen‐presenting cells. This process also requires other molecular interactions, which transmit co‐stimulatory signals to these T cells. To ensure an effective immune response, distinct T cell subsets may additionally employ unique mechanism(s) for efficient activation. **Results:** We here show that mutant CD8^+^ T cells lacking the IFN‐α/β signalling components are hyporesponsive to antigen stimulation __in vitro__. We further show that IFN‐α/β‐mediated signals are required for induction of the chemokines IP‐10/I‐TAC and their common receptor, CXCR3, and in turn provide evidence that CXCR3‐mediated signals indeed function in the activation and proliferation of CD8^+^ T cells, particularly for the CD44^low^ naive phenotype cells. **Conclusion:** The CXCR3 chemokine system is regulated by IFN‐α/β in CD8^+^ T cells, and it is critical for the efficient cell activation. The present study therefore reveals a novel role of the IFN‐α/β–CXCR3 signalling cascade in CD8^+^ T cell activation.
Who reads Requirement of the IFN‐α/β‐induced CXCR3 chemokine signalling for CD8^+^ T cell activation?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Kouetsu Ogasawara; Shigeaki Hida; Youmin Weng; Akio Saiura; Kojiro Sato; Hiroshi Takayanagi; Shinya Sakaguchi; Taeko Yokochi; Tatsuhiko Kodama; Makoto Naitoh; Julie A. De Martino; Tadatsugu Taniguchi
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 1356-9597)
- Published
- 2002
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)