Can I read Cellular and Subcellular Contact Guidance on Microfabricated Substrates on EtoBox?

Cellular and Subcellular Contact Guidance on Microfabricated Substrates by Leclech, Claire; Villard, Catherine is a Engineering article available to read on EtoBox.

What is Cellular and Subcellular Contact Guidance on Microfabricated Substrates about?

Topography of the extracellular environment is now recognized as a major biophysical regulator of cell behavior and function. The study of the influence of patterned substrates on cells, named contact guidance, has greatly benefited from the development of micro and nano-fabrication techniques, allowing the emergence of increasingly diverse and elaborate engineered platforms. The purpose of this review is to provide a comprehensive view of the process of contact guidance from cellular to subcellular scales. We first classify and illustrate the large diversity of topographies reported in the literature by focusing on generic cellular responses to diverse topographical cues. Subsequently, and in a complementary fashion, we adopt the opposite approach and highlight cell type-specific responses to classically used topographies (arrays of pillars or grooves). Finally, we discuss recent advances on the key subcellular and molecular players involved in topographical sensing. Throughout the review, we focus particularly on neuronal cells, whose unique morphology and behavior have inspired a large body of studies in the field of topographical sensing and revealed fascinating cellular mechan

Who reads Cellular and Subcellular Contact Guidance on Microfabricated Substrates?

Author

Leclech, Claire; Villard, Catherine

Publisher

Frontiers Media SA; Frontiers Media S.A.; Lausanne: Frontiers Media S.A., 2013- (ISSN 2296-4185)

Published

2020

Language

EN

Field

Engineering (Physical Sciences)