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This document summarizes the development and evaluation of an in vitro rat intestine segmental perfusion model to investigate drug permeability and predict oral drug absorption in humans. The model consists of a perfusion cell containing a rat intestinal segment and three circulations. Eight drugs with varying oral absorption were used to validate the model. A strong correlation (0.98) was found between in vivo human oral absorption and the ratio of drug to marker permeability coefficients in the model. The

Author

tvvsagar

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EN