Can I read Uncoupling in the Wall of the Cartilaginous Bronchus of the Pig Produced by Smooth Muscle Contraction on EtoBox?

Uncoupling in the Wall of the Cartilaginous Bronchus of the Pig Produced by Smooth Muscle Contraction by H.W. Mitchell; P.R. Gray is a Medicine article available to read on EtoBox.

What is Uncoupling in the Wall of the Cartilaginous Bronchus of the Pig Produced by Smooth Muscle Contraction about?

Studies in small non-cartilaginous airways suggest that the cross sectional area of the airway wall (comprising the smooth muscle and mucosa) is unaltered during the contraction-relaxation cycle produced by bronchial provocation. In the present study we examined whether the wall area of large cartilaginous bronchi remained constant during bronchoconstriction produced by acetylcholine (ACh, 10 -4 -10 -2 M), and if not the effect of this on the narrowing of the bronchial lumen. Narrowing of the lumen and adventitia of bronchial segments, 3.6 mm id from pigs, was simultaneously recorded using endoscopy and video imaging of the airway lumen. Concurrently, the shortening of the smooth muscle was estimated morphometrically from the same bronchi fixed during muscle contraction. In individual bronchi, ACh produced from 5 to 60% shortening of the smooth muscle, which caused up to 64% narrowing of the bronchial lumen, but only approximately 10% narrowing of the adventitia. Lumen narrowing was greater than predicted. Morphological assessment showed a doubling of the area between the smooth muscle and the cartilage, in response to maximum smooth muscle contraction by ACh. In contrast the area

Who reads Uncoupling in the Wall of the Cartilaginous Bronchus of the Pig Produced by Smooth Muscle Contraction?

Author

H.W. Mitchell; P.R. Gray

Publisher

Elsevier ; Academic Press; Elsevier BV (ISSN 0952-0600)

Published

1996

Language

EN

Field

Medicine (Health Sciences)