Can I read Acute kidney injury in severe sepsis: Pathophysiology, diagnosis, and treatment recommendations on EtoBox?

Acute kidney injury in severe sepsis: Pathophysiology, diagnosis, and treatment recommendations by Iain Keir; John A. Kellum is a Medicine article available to read on EtoBox.

What is Acute kidney injury in severe sepsis: Pathophysiology, diagnosis, and treatment recommendations about?

## Objective: To review the unique pathophysiology of sepsis-induced acute kidney injury (aki) and highlight the relevant aspects of the kidney disease: improving global outcomes (kdigo) clinical practice guideline for acute kidney injury that may apply to veterinary patients. ## Data sources: Electronic search of medline database. ## Human data synthesis: Sepsis-induced aki is diagnosed in up to 47% of human icu patients and is seen as a major public health concern associated with increased mortality and increased progression to chronic kidney disease (ckd). consensus criteria for the definition and classification of aki has allowed for accurate description of the epidemiology of patients with aki. aki develops from a complex relationship between the initial insult and activation of inflammation and coagulation. in contrast to the traditional view, clinical and experimental data dispute the role of renal ischemia-reperfusion in the development of sepsis-induced aki. renal tubular dysfunction with activation of the tubuloglomerular feedback mechanism appears to be a crucial contributor to sepsis-induced aki. furosemide and n-acetylcysteine (nac) do not appear to be helpful in the t

Who reads Acute kidney injury in severe sepsis: Pathophysiology, diagnosis, and treatment recommendations?

Author

Iain Keir; John A. Kellum

Publisher

Wiley

Published

2015

Language

EN

Field

Medicine (Health Sciences)