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Comparison of treatments of chronic hepatitis B in children with lamivudine and α-interferon combination and α-interferon alone by Bunyamin Dikici; Mehmet Bosnak; Vuslat Bosnak; Abdullah Dagli; Mehmet Davutoglu; Rasit Vural Yagci; Kenan Haspolat is a Medicine article available to read on EtoBox.

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## Abstract **__Background__**: The aim of this study was to compare the efficacy of the α‐interferon treatment with treatment using α‐interferon and lamivudine in combination for cases of childhood chronic hepatitis B infection. **__Methods__**: Patients were evaluated in two groups retrospectively. In group 1, 27 patients were simultaneously given α‐interferon 2b 10 MU/m^2^, 3 days a week by s.c. injection plus lamivudine 4 mg/kg a day (maximum 100 mg) for 12 months. In group 2, there were 13 patients who only received the same dosage of α‐interferon and no lamivudine over the same period of time. **__Results__**: In group 1 the initial mean value of alanine aminotransferase (ALT) was 121 ± 66 IU/L and decreased to 27.8 ± 11.5 IU/L; in group 2, initial mean values of ALT was 129 ± 46 IU/L and decreased to 60 ± 6 IU/L at the end of the twelfth month of the therapy (__P__ < 0.05). Hepatitis B virus DNA (HBV‐DNA) clearance was obtained in all group 1 patients and six of 13 patients in group 2 at the end of the therapy (__P__ 0.05). The number of patients with complete response was found to be 10 out of 27 (37%) in group 1 and four out of 13 cases (30.7%) in group 2, 6 months after

Who reads Comparison of treatments of chronic hepatitis B in children with lamivudine and α-interferon combination and α-interferon alone?

Author

Bunyamin Dikici; Mehmet Bosnak; Vuslat Bosnak; Abdullah Dagli; Mehmet Davutoglu; Rasit Vural Yagci; Kenan Haspolat

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 1328-8067)

Published

2002

Language

EN

Field

Medicine (Health Sciences)