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Real-world Application of Oral Therapy for Infective Endocarditis: A Multicenter Retrospective, Cohort Study by Sarah Freling; Noah Wald-Dickler; Josh Banerjee; Catherine P Canamar; Soodtida Tangpraphaphorn; Dara Bruce; Kusha Davar; Fernando Dominguez; Daniel Norwitz; Ganesh Krishnamurthi; Lilian Fung; Ashley Guanzon; Emi Minejima; Michael Spellberg; Catherine Spellberg; Rachel Baden; Paul Holtom; Brad Spellberg is a Medicine article available to read on EtoBox.

What is Real-world Application of Oral Therapy for Infective Endocarditis: A Multicenter Retrospective, Cohort Study about?

Abstract Background We sought to compare the outcomes of patients treated with intravenous (IV)-only vs. oral transitional antimicrobial therapy for infective endocarditis (IE) after implementing a new Expected Practice within The Los Angeles County Department of Health Services (LAC DHS). Methods We conducted a multi-centered, retrospective cohort study of adults with definite or possible IE treated with IV-only vs. oral therapy at the three acute care, public hospitals in the LAC DHS system between December 2018 to June 2022. The primary outcome was clinical success at 90 days, defined as being alive, and without recurrence of bacteremia or treatment-emergent infectious complications. Results We identified 257 patients with IE treated with IV-only (n=211) or oral transitional (n=46) therapy who met study inclusion criteria. Study arms were similar for many demographics; however, the IV cohort was older, and had more aortic valve involvement, hemodialysis patients, and central venous catheters present. In contrast, the oral cohort had a higher percentage of IE caused by methicillin-resistant S. aureus. There was no significant difference between the groups in clinical success at 9

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Author

Sarah Freling; Noah Wald-Dickler; Josh Banerjee; Catherine P Canamar; Soodtida Tangpraphaphorn; Dara Bruce; Kusha Davar; Fernando Dominguez; Daniel Norwitz; Ganesh Krishnamurthi; Lilian Fung; Ashley Guanzon; Emi Minejima; Michael Spellberg; Catherine Spellberg; Rachel Baden; Paul Holtom; Brad Spellberg

Publisher

Oxford University Press (OUP)

Published

2023

Language

EN

Field

Medicine (Health Sciences)