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Ursodeoxycholic Acid and Endothelial-dependent, Nitric Oxide-independent Vasodilatation of Forearm Resistance Arteries in Patients with Coronary Heart Disease by Juha Sinisalo; Hannu Vanhanen; Pia Pajunen; Heikki Vapaatalo; Markku S. Nieminen is a Medicine article available to read on EtoBox.

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__Aims__ Ursodeoxycholic acid (UDCA) has cholesterol lowering and anti‐inflammatory effects and bile acids are reported to exert vasodilator effects; all of these properties might be considered desirable in a drug used in the treatment of patients with coronary heart disease. We investigated a hypothesis that UDCA may dilate arteries and the mechanism of action. __Methods We evaluated effects of a 6‐week treatment with UDCA in 11 coronary heart disease patients on endothelium‐dependent (acetylcholine‐induced) and ‐independent (nitroprusside‐induced) vasodilatations in forearm vasculature by strain‐gauge plethysmography. Healthy individuals (n__=14) served as baseline controls. __Results The percentage increase by acetylcholine in the flow of the infused arm relative to the non‐infused arm of coronary heart disease patients during the trial remained unaltered, but vasodilatation to N^G^‐monomethyl‐l‐arginine+acetylcholine was improved by 161±27% with UDCA vs 83±22% with placebo (mean difference 91% [95% CI 35%, 147%], P__=0.016). __Conclusions__ Six weeks’ UDCA therapy improved endothelium‐dependent nitric oxide‐independent vasodilatation, which might maintain arterial flow in coron

Who reads Ursodeoxycholic Acid and Endothelial-dependent, Nitric Oxide-independent Vasodilatation of Forearm Resistance Arteries in Patients with Coronary Heart Disease?

Author

Juha Sinisalo; Hannu Vanhanen; Pia Pajunen; Heikki Vapaatalo; Markku S. Nieminen

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley; Research Square (ISSN 0306-5251)

Published

1999

Language

EN

Field

Medicine (Health Sciences)